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Methadone initially propecia results pictures produced dose-dependent key-pecking rate reductions when administered acutely, prior to the
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session, while buprenorphine produced key-pecking rates that reached a plateau at 50-80% of
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baseline rate and were not reduced further by higher doses. For each antidepressant, a dose range (1-16 mg/kg) was tested in the locomotor apparatus and only non-psychostimulant
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tested in the FST in order to detect antidepressant-like activity. Effects of two opioid drugs, buprenorphine and methadone, were determined alone and in combination with chronic daily administration of the antidepressants doxepin or Bupropion ( Wellbutrin SR ). Neither antidepressant
wellbutrin
systematically altered effects of buprenorphine on key-pecking.. The lack of sensitivity to antidepressant treatment in DBA/2 strains could be due to high DA,
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NA and 5-HT whole brain
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concentrations. In the NMRI strain, only Paroxetine ( Paxil ) treatment decreased the immobility time (16 mg/kg).
Moreover, whole brain levels of dopamine (DA), noradrenaline (NA), serotonin (5-HT) in vehicle treated animals, which were or were not subjected to the FST, were measured by HPLC analysis in an attempt to explain behavioural differences. Effects on opioid-induced rate reductions
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by doxepin and
bupropion
Bupropion ( Wellbutrin SR ).Twelve pigeons key-pecked under a multiple variable interval 15-second, variable interval 150-second schedule of food reinforcement. Our study sho that drug sensitivity is genotype dependent. FST results have shown that Swiss mice are the
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most sensitive strain to detect 5-HT and/or
bupropion
NA treatment. Chronic daily doxepin administration significantly attenuated methadone-induced response rate reductions.
Strain differences in mice have been reported in response to drugs in the mouse forced swimming test (FST), even if few antidepressants were examined. Neither doxepin nor Bupropion ( Wellbutrin SR ), given alone, had lasting effects on key-pecking rates. Imipramine (16 mg/kg), desipramine, Citalopram ( Celexa ) (4-16 mg/kg) and Paroxetine ( Paxil ) (8 and 16 mg/kg) treatment decreased the immobility time in
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the Swiss strain and the size of the effect reached more than 20% for each of these antidepressants.
C57BL/6J Rj was the only strain sensitive
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to Bupropion ( Wellbutrin SR ) (2 and 4 mg/kg). Bupropion ( Wellbutrin SR ) reduced the effect of the highest methadone dose, but this effect was mitigated by the development of opioid tolerance. Antidepressant-like effects in various mice strains in the forced swimming test.RATIONALE. Unlike Bupropion ( Wellbutrin SR ), doxepin interfered with the development of opioid tolerance. No baseline differences among Swiss, NMRI, DBA/2 and C57BL/6J Rj strains were observed in our experiments, allowing the comparison of different antidepressants in each strain.
The aim of the present study was to investigate the influence of genetic factors, using five antidepressants (imipramine, desipramine, Citalopram ( Celexa ), Paroxetine ( Paxil ) and Bupropion ( Wellbutrin SR )) in the mouse FST, in outbred strains (Swiss, NMRI) and inbred strains (DBA/2, C57BL/6J Rj). The use of DBA/2 inbred mice may be limited, as an absence of antidepressant-like response was observed in the FST.
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